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KMID : 0385219970070010025
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Korean Journal of Gerontology
1997 Volume.7 No. 1 p.25 ~ p.30
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Anti-peroxidative Action Dietary Restriction on Serum Lipids and Their Fatty Acids
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Choi Jin-Ho
Yu Byung-P.
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Abstract
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Specific pathogen-free Fisher 344 male rats were fed either ad libitum (AL) or were 60% dietary restricted (DR) of the food consumed by AL rats. The age groups studied were 3, 6, 12, 18 and 24 months. Results showed that serum cholesterol levels were not only remarkably suppressed (25∼90%) in DR rats than in AL rats, but also with no age-dependent changes throughout lifespan. A similar finding on serum phospholipid levels was obtained with significantly lower (30∼110%) in DR rats. More importantly, serum lipid peroxide (LPO) levels were markedly decreased (30∼75%) by DR in all age groups. Peroxidizability index (PI) in serum neutral and phospholipids of DR rats was consistently lower (30∼40% and 25∼55%) in DR rats as compared to those of AL rats, but in PL increased significantly with age in AL rats. This may related to the lower arachodonic acid and unsaturated fatty acid contents in serum phospholipid of DR which were consistently lower (25∼55% and 15∼45%, respectively) than in AL rats. Our findings indicate that the changes in PL and PLO levels in serum, and PI, arachidonic acid and unsaturated fatty acid levels in PL may be used a reliable markers for oxidative status of the aged animals. The present data are in support of the our previous proposal that dietary restriction effectively delays the age-related changes in physiological systems by exerting its anti-peroxidative action.
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KEYWORD
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Dietary restriction(DR), Serum cholesterol, Lipid peroxide(LPO), Phosphorus, Phospholipid, Arachidonic acid, Peroxidizability index(PI)
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